American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
-
Am J Health Syst Pharm · Sep 2011
Case ReportsReadministration of drotrecogin alfa (activated) in an adult with severe sepsis.
The case of a patient with severe, multidrug-resistant, postoperative sepsis who was successfully treated with drotrecogin alfa (activated) on two occasions is reported. ⋯ A patient received two complete courses of drotrecogin alfa (activated) without any treatment-related complications.
-
Am J Health Syst Pharm · Sep 2011
Randomized Controlled Trial Comparative StudyEffect of ascorbic acid on inflammatory markers after cardiothoracic surgery.
The effect of ascorbic acid on inflammatory markers after cardiothoracic surgery (CTS) was studied. ⋯ Ascorbic acid did not attenuate the rise in inflammatory markers after CTS when compared with placebo. The use of off-pump surgery did not significantly change the levels of CRP and fibrinogen or the WBC count postoperatively when compared with on-pump surgery with a biocompatible polymer coating.
-
Am J Health Syst Pharm · Aug 2011
Review Comparative StudyRationale and evidence for extended infusion of piperacillin-tazobactam.
The pharmacodynamics and therapeutic effects of extended-infusion (EI) piperacillin-tazobactam therapy are reviewed, with an emphasis on growing evidence of its advantages over traditional infusion schemes. ⋯ The pharmacodynamic profile of EI piperacillin-tazobactam therapy; evidence of its benefits over traditional 30-minute infusions in terms of mortality, duration of hospitalization, clinical and microbiological cure rates, and reduction of fever; and EI's lower total treatment cost suggest that EI may be the superior mode of administration.