American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
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The role of protein C in critical illness is assessed. ⋯ The protein C pathway is a natural homeostatic regulator with multiple mechanisms of action. Blood protein C concentration is inversely correlated with morbidity and mortality in sepsis and other critical illness.
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Am J Health Syst Pharm · Jun 2009
Case ReportsElevated creatine phosphokinase levels associated with linezolid therapy.
A case of elevated creatine phosphokinase (CPK) levels associated with linezolid therapy in a patient on chronic antihyperlipidemic therapy is presented. ⋯ A patient on chronic antihyperlipidemic therapy developed elevated CPK levels after receiving linezolid for the treatment of MRSA pneumonia.
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Am J Health Syst Pharm · Jun 2009
Effect of bar-code-assisted medication administration on medication error rates in an adult medical intensive care unit.
The effect of bar-code-assisted medication administration (BCMA) on the rate of medication errors in adult patients in a medical intensive care unit (ICU) was studied. ⋯ The implementation of BCMA significantly reduced the number of wrong administration time errors in an adult medical ICU.
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Am J Health Syst Pharm · Jun 2009
Meta Analysis Comparative StudyPharmacokinetics of extended-release epidural morphine sulfate: pooled analysis of six clinical studies.
A pooled analysis of six clinical studies was conducted to describe the pharmacokinetics of extended-release epidural morphine sulfate. ⋯ A pooled analysis of six studies revealed that extended-release epidural morphine sulfate provided a more prolonged release of morphine compared with standard epidural morphine sulfate. Extended-release epidural morphine sulfate displayed a consistent pharmacokinetic profile among adults, with only slight variability between men and women in C(max), which appeared to be mainly caused by differences in body weight.