Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Jan 2012
Multicenter Study Clinical TrialNanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: an open-label trial.
Hereditary angioedema (HAE) is a rare disease caused by C1INH gene mutations, which leads to a deficiency or dysfunction of C1 inhibitor (C1 INH), resulting in recurrent episodes of severe and potentially life-threatening edema. ⋯ This open-label study demonstrates the efficacy and safety of C1 INH-nf for short-term treatment of HAE attacks.
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Ann. Allergy Asthma Immunol. · Dec 2011
Randomized Controlled Trial Multicenter StudyRandomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial.
The For Angioedema Subcutaneous Treatment (FAST)-3 study was a phase III, randomized, double-blind, placebo-controlled study of icatibant (bradykinin B(2) receptor antagonist) in subjects with hereditary angioedema (HAE) resulting from C1-INH deficiency or dysfunction (type I/II). ⋯ FAST-3 demonstrated that icatibant was effective and generally well tolerated in subjects with acute HAE attacks.
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Ann. Allergy Asthma Immunol. · Oct 2011
Comparative StudyComparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry.
Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects. ⋯ Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression.
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Ann. Allergy Asthma Immunol. · Sep 2011
Written action plan use in inner-city children: is it independently associated with improved asthma outcomes?
Guidelines from the National Asthma Education and Prevention Program stipulate that multicomponent self-management interventions for asthma should include a written action plan (WAP). However the specific, independent effect of WAPs in improving outcomes remains unclear. ⋯ WAP use during the previous year was not associated with improved outcomes compared with non-use. Additional studies are needed to assess the long-term, independent benefit of this universally recommended intervention.