The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
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Over the past few years, the control of pain exerted by glial cells has emerged as a promising target against pathological pain. Indeed, changes in glial phenotypes have been reported throughout the entire nociceptive pathway, from peripheral nerves to higher integrative brain regions, and pharmacological inhibition of such glial reactions reduces the manifestation of pain in animal models. ⋯ In addition, given the large number of functions accomplished by glial cells, various mechanisms might sensitize nociceptive neurons including a release of pronociceptive cytokines and neurotrophins or changes in neurotransmitter-scavenging capacity. The authors review the conceptual advances made in the recent years about the implication of central and peripheral glia in animal models of chronic pain and discuss the possibility to translate it into human therapies in the future.
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Sex differences in the brain are reflected in behavior and in the risk for neuropsychiatric disorders. The fetal brain develops in the male direction due to a direct effect of testosterone on the developing neurons, or in the female direction due to the absence of such a testosterone surge. Because sexual differentiation of the genitals takes place earlier in intrauterine life than sexual differentiation of the brain, these two processes can be influenced independently of each other. ⋯ There is no proof that postnatal social environment has any crucial effect on gender identity or sexual orientation. Structural and functional sex differences in brain areas, together with changes in sex hormone levels and their receptors in development and adulthood, are closely related to sex differences in behavior and neuropsychiatric disorders. Knowing that such a relationship exists may help bring about sex-specific therapeutic strategies.
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Adult primary sensory cortex is not hard wired, but adapts to sensory experience. The cellular basis for cortical plasticity involves a combination of functional and structural changes in cortical neurons and the connections between them. Functional changes such as synaptic strengthening have been the focus of many investigations. ⋯ In this review, the authors focus on structural remodeling that leads to rewiring of cortical circuits. Recent work has identified axonal remodeling, growth of new dendritic spines, and synapse turnover as important structural mechanisms for experience-dependent plasticity in mature cortex. These findings have begun to unravel how rewiring occurs in adult neocortex and offer new insights into the cellular mechanisms for learning and memory.
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Oligodendrocytes have received much attention in relation to neurological and psychiatric disorders. The involvement of oligodendrocytes and their myelin in normal brain functions has been suggested by many lines of evidence. ⋯ In this article, we summarize evidence for the ability of oligodendrocytes to monitor neuronal activity and for the facilitation of axonal conduction by oligodendrocytes by mechanisms other than myelination. We suggest the underlying mechanisms for this facilitation in relation to the morphological dynamics of myelinating processes and discuss the physiological roles of the facilitation in information processing.
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Synaptic plasticity, the ability of neurons to change the number and strength of their synapses, has long been considered the sole province of the neuron. Yet neurons do not function in isolation; they are a part of elaborate glial networks where they are intimately associated with astrocytes. ⋯ During periods of synaptogenesis, astrocyte processes are highly mobile and may contribute to the stabilization of new synapses. As our understanding of the extent of their influence at the synapse unfolds, it is clear that astrocytes are well poised to modulate multiple aspects of synaptic plasticity.