Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Oct 2006
A proposed score for predicting severe infection complications in children with chemotherapy-induced febrile neutropenia.
Febrile neutropenia (FN) is one of most common complications in patients with cancer during chemotherapy. Identifying factors associated with severe infectious complications (SICs) at time of admission for fever and neutropenia is necessary for better treatment. ⋯ This study suggests that patients with FN can be stratified for risk of SIC using clinical parameters at hospital admission.
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J. Pediatr. Hematol. Oncol. · Aug 2006
Comparative StudyPainful episodes in children with sickle cell disease and asthma are temporally associated with respiratory symptoms.
Little is known about the temporal relationship between an asthma exacerbation and a painful episode in a child with sickle cell disease (SCD). We tested the hypothesis that respiratory symptoms either immediately precede or occur concomitantly with painful episodes more frequently in children with SCD and asthma when compared with children with SCD without asthma. ⋯ In children with both SCD and asthma, respiratory symptoms are a risk factor for painful episodes within 96 hours.
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J. Pediatr. Hematol. Oncol. · Aug 2006
Case ReportsAggressive Digital Papillary Adenocarcinoma in a 15-year-old Female.
Aggressive digital papillary adenocarcinoma is a rare neoplasm of eccrine sweat gland origin that typically presents as a mass on a finger, toe, or the adjacent skin. Less than 100 cases have been reported. The majority of these cases are described in males in their fifth to seventh decade. ⋯ Two sentinel lymph nodes were biopsied and found to be negative for metastatic disease. One year after surgery the patient has no evidence of disease recurrence. To our knowledge, this is the youngest reported case of an aggressive digital papillary adenocarcinoma.
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J. Pediatr. Hematol. Oncol. · Jun 2006
Case ReportsMethemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura.
This report describes a case of methemoglobinemia in association with dapsone therapy. The patient, an immunocompromised child with chronic immune thrombocytopenic purpura, presented with fever, cough, perioral cyanosis, bilateral lower lobe rales, and low O2 saturation by pulse oximetry (89%). ⋯ The authors discuss the mechanism and treatment of methemoglobinemia secondary to dapsone. They also stress the importance of monitoring for signs and symptoms of methemoglobinemia in immunocompromised patients on dapsone therapy for P. carinii pneumonia prophylaxis.
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J. Pediatr. Hematol. Oncol. · May 2006
Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients.
Clinical complications resulting from unevenly iron accumulation in individual organs of patients with beta-thalassemia major can affect both expectancy and quality of life. Magnetic resonance imaging (MRI) offers a quantitative, noninvasive, accurate method for estimating iron levels in various tissues, not easily accessible with other techniques. The aim of this study was to evaluate and correlate the level of iron accumulation in different organs (anterior pituitary, myocardium, and liver) assessed with MRI, in children and young adults with beta-thalassemia major. ⋯ In conclusion, iron accumulation in thalassemic patients is a procedure progressing with age, which seems to act independently in different organs. MRI represents a reliable, noninvasive method for assessing iron overload in various tissues, non-easily accessible with other techniques. Regular scanning, to recognize preclinically excessive iron deposits and intensified chelation therapy, can prevent serious and fatal complications.