European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
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Eur J Vasc Endovasc Surg · Dec 2001
ReviewCytokines and inflammatory pathways in the pathogenesis of multiple organ failure following abdominal aortic aneurysm repair.
Multiple organ failure is a common mode of death following abdominal aortic aneurysm repair, particularly after rupture. Cytokines are the principal mediators of the inflammatory response to injury and high levels of circulating cytokines have been associated with poor outcome in major trauma and sepsis. Abdominal aortic aneurysm repair results in an ischaemia-reperfusion injury to the tissues distal to the site of aortic clamping. ⋯ If released in large enough concentrations, these cytokines may enter the circulation and gain access to organs distant to the site of initial injury. Circulating cytokines cause dysfunction of the renal, cardiovascular, respiratory, nervous and musculo-skeletal systems. The combination of these individual changes in organ function is the multiple-organ dysfunction syndrome, which may progress to multiple organ failure.
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Eur J Vasc Endovasc Surg · Nov 2001
Randomized Controlled Trial Clinical Trial"Long haul" flight and deep vein thrombosis: a model to help investigate the benefit of aspirin and below-knee compression stockings.
to develop a model simulating factors of "long haul" flight to investigate the relationship with DVT. ⋯ changes in the cellular components of blood, particularly WBC's, combined with vaso-compression and reduced flow could predispose towards DVT. Aspirin, combined with compression stockings, may provide prophylaxis.
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Eur J Vasc Endovasc Surg · Nov 2001
Remifentanil conscious sedation during regional anaesthesia for carotid endarterectomy: rationale and safety.
to prospectively evaluate the safety and efficacy of remifentanil during regional anaesthesia for carotid endarterectomy. ⋯ remifentanil as a supplement to regional anaesthesia for carotid endarterectomy, provides comfort and analgesia without hampering mental status evaluation.