Annals of internal medicine
-
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. ⋯ Daily low-dose aspirin beginning as early as the second trimester prevented clinically important health outcomes. No harms were identified, but long-term evidence was limited.
-
Comparative Study
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
Vaccination for the 2009 pandemic did not occur until late in the outbreak, which limited its benefits. Influenza A (H7N9) is causing increasing morbidity and mortality in China, and researchers have modified the A (H5N1) virus to transmit via aerosol, which again heightens concerns about pandemic influenza preparedness. ⋯ Agency for Healthcare Research and Quality, National Institutes of Health, and Department of Veterans Affairs.
-
Childhood cancer survivors treated with anthracyclines are at high risk for asymptomatic left ventricular dysfunction (ALVD), subsequent heart failure, and death. The consensus-based Children's Oncology Group (COG) Long-Term Follow-up Guidelines recommend lifetime echocardiographic screening for ALVD. ⋯ The COG guidelines could reduce the risk for heart failure in survivors at less than $100 000/QALY. Less frequent screening achieves most of the benefits and would be more cost-effective than the COG guidelines.
-
Review Meta Analysis Comparative Study
Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Biological agents are emerging treatment options for the management of ulcerative colitis (UC). ⋯ Biological agents are effective treatments for UC, but head-to-head trials are warranted to establish the best therapeutic option.
-
Practice Guideline
Screening for suicide risk in adolescents, adults, and older adults in primary care: U.S. Preventive Services Task Force recommendation statement.
Update of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for suicide risk. ⋯ The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for suicide risk in adolescents, adults, and older adults in a primary care setting. (I statement).