Annals of internal medicine
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Review Meta Analysis Comparative Study
Biological agents for moderately to severely active ulcerative colitis: a systematic review and network meta-analysis.
Biological agents are emerging treatment options for the management of ulcerative colitis (UC). ⋯ Biological agents are effective treatments for UC, but head-to-head trials are warranted to establish the best therapeutic option.
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Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. ⋯ Daily low-dose aspirin beginning as early as the second trimester prevented clinically important health outcomes. No harms were identified, but long-term evidence was limited.
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Comparative Study
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study.
Vaccination for the 2009 pandemic did not occur until late in the outbreak, which limited its benefits. Influenza A (H7N9) is causing increasing morbidity and mortality in China, and researchers have modified the A (H5N1) virus to transmit via aerosol, which again heightens concerns about pandemic influenza preparedness. ⋯ Agency for Healthcare Research and Quality, National Institutes of Health, and Department of Veterans Affairs.