Annals of internal medicine
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In this issue, Fisher and colleagues report the results of a nationally representative U. S. survey that found that only approximately 6 in 10 respondents said that they will get vaccinated when a vaccine for coronavirus disease 2019 becomes available. The editorialist discusses the findings and why closing the intention-to-behavior gap for those willing to be vaccinated rather than focusing on those hesitant about vaccination is likely to have the population health benefit.
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In comparative studies, treatment effect is often assessed using a binary outcome that indicates response to the therapy. Commonly used summary measures for response include the cumulative and current response rates at a specific time point. The current response rate is sometimes called the probability of being in response (PBIR), which regards a patient as a responder only if they have achieved and remain in response at present. ⋯ Although discussed extensively in the statistical literature, estimation of the current response rate curve has garnered little attention in the medical literature. This article illustrates how to construct and analyze such a curve using data from a recent study for treating renal cell carcinoma. Clinical trialists are encouraged to consider this robust and clinically interpretable procedure as an additional tool for evaluating treatment effects in clinical studies.