Annals of internal medicine
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Comment Randomized Controlled Trial
In patients with CHD, a Mediterranean vs. low-fat diet reduced major CV events at 7 y.
Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet. 2022;399:1876-85. 35525255.
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Comment Meta Analysis
In ischemic stroke, IV alteplase within 3 h of onset improves functional outcome vs. control.
Mun KT, Bonomo JB, Liebeskind DS, et al. Fragility index meta-analysis of randomized controlled trials shows highly robust evidential strength for benefit of < 3 hour intravenous alteplase. Stroke. 2022;53:2069-74. 35543129.
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Comment Meta Analysis
In older LTC residents, transitional care interventions vs. usual care reduce hospital readmissions.
Birtwell K, Planner C, Hodkinson A, et al. Transitional care interventions for older residents of long-term care facilities: a systematic review and meta-analysis. JAMA Netw Open. 2022;5:e2210192. 35507344.
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Practice Guideline
Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma.
Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed clinical practice guidelines for the appropriate use of CCP. ⋯ CCP is most effective when transfused with high neutralizing titers to infected patients early after symptom onset.
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Centers for Disease Control and Prevention (CDC) defines low, medium, and high "COVID-19 community levels" to guide interventions, but associated mortality rates have not been reported. ⋯ Council of State and Territorial Epidemiologists.