Annals of internal medicine
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Comment Randomized Controlled Trial
In minor, nondisabling, acute ischemic stroke, DAPT was noninferior to IV alteplase for excellent functional outcome at 90 d.
Chen HS, Cui Y, Zhou ZH, et al; ARAMIS Investigators. Dual antiplatelet therapy vs alteplase for patients with minor nondisabling acute ischemic stroke: the ARAMIS randomized clinical trial. JAMA. 2023;329:2135-2144. 37367978.
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Comment Randomized Controlled Trial
Cytisinicline increased smoking abstinence at 6 and 12 wk.
Rigotti NA, Benowitz NL, Prochaska J, et al. Cytisinicline for smoking cessation: a randomized clinical trial. JAMA. 2023;330:152-160. 37432430.
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Substantial effort has been directed toward demonstrating uses of predictive models in health care. However, implementation of these models into clinical practice may influence patient outcomes, which in turn are captured in electronic health record data. As a result, deployed models may affect the predictive ability of current and future models. ⋯ National Center for Advancing Translational Sciences.
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Observational Study
Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events : A Cohort Study.
Not enough is known about the association between blood pressure (BP) in adolescence and future cardiovascular events. ⋯ Västerbotten County Council, Swedish Society for Medical Research, and Heart Foundation of Northern Sweden.
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Wharton S, Blevins T, Connery L, et al; GZGI investigators. Daily oral GLP-1 receptor agonist orforglipron for adults with obesity. N Engl J Med. 2023;389:877-880. 37351564.