Annals of internal medicine
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Comment Meta Analysis
Statins increase muscle pain or weakness at 1 y, with an absolute excess of 11 events/1000 person-y.
Cholesterol Treatment Trialists' Collaboration. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. Lancet. 2022;400:832-45. 36049498.
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Clinicians and patients want to know the benefits and harms of outpatient treatment options for SARS-CoV-2 infection. ⋯ American College of Physicians. (PROSPERO: CRD42022323440).
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Randomized Controlled Trial Multicenter Study
Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease : A Randomized Controlled Trial.
Older patients with advanced chronic kidney disease (CKD) face difficult decisions about managing kidney failure, frequently experiencing decisional conflict, regret, and treatment misaligned with preferences. ⋯ Patient-Centered Outcomes Research Institute (PCORI).
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Comment Randomized Controlled Trial
In glucocorticoid-dependent polymyalgia rheumatica, tocilizumab improved a composite clinical outcome at 24 wk.
Devauchelle-Pensec V, Carvajal-Alegria G, Dernis E, et al. Effect of tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy: a randomized clinical trial. JAMA. 2022;328:1053-62. 36125471.
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Randomized Controlled Trial
Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease : A Post Hoc Analysis of DAPA-CKD.
Acute hospitalizations are common in patients with chronic kidney disease (CKD) and often lead to decreases in health-related quality of life and increased care costs. ⋯ AstraZeneca.