Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis : A Randomized Controlled Multicenter Trial.
The benefits of exercise in patients with knee osteoarthritis are well documented, but the optimal exercise dose remains unknown. ⋯ Swedish Rheumatic Fund.
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Comment Randomized Controlled Trial
In basilar-artery occlusion stroke, thrombectomy improved functional outcomes without increasing ICH.
Jovin TG, Li C, Wu L, et al. Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med. 2022;387:1373-84. 36239645.
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Hydroxychloroquine is recommended for all patients with systemic lupus erythematosus and is often used for other inflammatory conditions, but a critical long-term adverse effect is vision-threatening retinopathy. ⋯ National Institutes of Health.
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Comment Randomized Controlled Trial
In high-risk outpatients with COVID-19, neither colchicine nor aspirin reduced disease progression or death at 45 d.
Eikelboom JW, Jolly SS, Belley-Cote EP, et al. Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial. Lancet Respir Med. 2022;10:1160-8. 36228639.