Annals of internal medicine
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Comment Randomized Controlled Trial
In primary care, second-line IBS therapy with amitriptyline vs. placebo reduced symptoms at 6 mo.
Ford AC, Wright-Hughes A, Alderson SL, et al; ATLANTIS trialists. Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;402:1773-1785. 37858323.