Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
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Review Meta Analysis Comparative Study
Do meta-analyses reveal time-dependent differences between the clinical outcomes achieved by microfracture and autologous chondrocyte implantation in the treatment of cartilage defects of the knee?
To test the hypothesis that autologous chondrocyte implantation (ACI) has a better treatment effect than microfracture (MF), and increasing superiority over the years, when performed under similar patient-specific and defect-specific conditions. ⋯ Both series of meta-analyses (combining either all ACI modifications or solely the second and third generations of ACI) suggest that the treatment effects resulting from ACI and MF converge over the years.
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Leg length discrepancy (LLD) following total hip arthroplasty (THA) is a leading cause of patient dissatisfaction. However, no reports have described the influence of lower limb alignment on LLD after THA. In the present study, we firstly investigated the change in lower limb alignment after THA. Secondly, we determined the influence of lower limb alignment on LLD after THA. Thirdly, we evaluated the influence of LLD in the entire lower leg on the clinical outcomes after THA. ⋯ LLD in the entire lower leg should be corrected for a better clinical outcome after THA.
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Previous studies reported that the publication rate of abstracts presented at overseas meetings was around 50 %. The study objectives were to determine the rate of publication in English-language journals and the impact factor (IF) for all papers presented at the Annual Meeting of the Japanese Orthopaedic Association (JOA) and Annual Research Meeting of the Japanese Orthopaedic Association (JOAR), and to compare the publication rates and IFs from abstracts accepted for oral versus poster presentations. ⋯ The rate from JOAR was similar to publication rates for abstracts presented at overseas orthopedic meetings, however, the rate from JOA was half that of publication rates for abstracts presented at overseas orthopedic meetings, indicating that JOA may provide a below average contribution of new medical data to the international scientific community. No significant difference in publication rates between oral and poster presentations were found, and this suggests a need for improvement of the review system for the annual meeting and that review scores at the meetings did not predict the publication fate of abstracts.
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Comparative Study
Behavioral and neuropathological changes in animal models of chronic painful scar.
Long-lasting limb pain or back pain after surgery occasionally develops into chronic pain that leads to lower activity and a poorer quality of life for many patients. To determine the histopathological and neuropathological mechanisms that cause persistent post-operative pain, we developed an original animal model with sustained painful scars and then examined pain-related behavior and the pathological alteration of peripheral tissues and spinal nerves associated with the model. ⋯ We created a persistent painful scar model through extensive injury of the peripheral tissues. Fibrotic thickening of the cutaneous tissues, possible sensitization, and partial degradation of the spinal nerve related to the painful scar were observed. This model should enable us to better understand the mechanism of sensitization caused by painful scar and investigate new methods for treating painful scars in humans.