Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
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The clinical relevance of D-dimer levels when screening for venous thromboembolism (VTE) in elderly patients with a hip fracture has been reported but has not been fully investigated in patients with fractures caused by high-energy injuries. The purpose of this study was to evaluate the usefulness and limitations of D-dimer in such patients. ⋯ D-dimer can be used as a VTE screening tool in patients with fractures caused by high-energy injuries. Our results suggested that D-dimer analysis to predict VTE was useful in patients with a pelvic fracture or multiple fractures. Our results also suggested that it was less useful for predicting VTE in patients with an isolated lower extremity fracture.
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Review Meta Analysis
The polymorphisms of melatonin receptor 1B gene (MTNR1B) (rs4753426 and rs10830963) and susceptibility to adolescent idiopathic scoliosis: a meta-analysis.
To determine whether MTNR1B rs4753426 and rs10830963 polymorphisms are correlated with AIS. Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, while its etiology remains uncertain. Melatonin receptor 1B (MTNR1B) gene polymorphisms have been found to be significantly associated with AIS risk; however, some of these results are controversial. ⋯ MTNR1B rs4753426 and MTNR1B rs10830963 polymorphisms are not obviously associated with risk of AIS in either Asian populations or Caucasian populations.
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Long fusion to the sacrum has been demonstrated to increase the mechanical failure rate after adult spinal deformity (ASD) surgery, and these mechanical failures are the most common etiology for reoperation. The purpose of this study was to determine the incidence and risk factors for mechanical failure associated with reoperation after spinal fusion to the sacrum in ASD. ⋯ Overall, 37 % of the patients who underwent ASD surgery involving the sacrum required reoperation for mechanical failure. The most frequent form of mechanical failure associated with reoperation was surgical PJK. Significant risk factors for mechanical failure included medical comorbidities, smoking, and severe preoperative sagittal imbalance. Critical mechanical failure may have a negative influence on health status.