Annals of surgery
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Comparative Study
Albumin protects against gut-induced lung injury in vitro and in vivo.
Since albumin has the ability to detoxify, we assessed whether low-dose albumin could protect against trauma/hemorrhagic shock (T/HS)-induced endothelial cell, lung, gut, and red blood cell (RBC) injury in vivo and endothelial cell injury in vitro. ⋯ Low-dose albumin protects against gut lymph-induced lung, HUVEC, and RBC injury by neutralizing T/HS lymph toxicity.
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To determine the efficacy of splenectomy for treating thrombocytopenia associated with systemic lupus erythematosus (SLE). ⋯ Splenectomy should be considered safe and efficacious for thrombocytopenia associated with SLE.
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Comment Letter
Are actual standard fluid regimens in major surgery safe?
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Randomized Controlled Trial Comparative Study Clinical Trial
The educational impact of bench model fidelity on the acquisition of technical skill: the use of clinically relevant outcome measures.
To evaluate the impact of bench model fidelity on the acquisition of technical skill using clinically relevant outcome measures. ⋯ Surgical skills training on low-fidelity bench models appears to be as effective as high-fidelity model training for the acquisition of technical skill among novice surgeons.
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Comparative Study
Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients.
This study aims to review the operative results and oncological outcomes of anterior resection for rectal and rectosigmoid cancer. Comparison was made between patients with total mesorectal excision (TME) for mid and distal cancer and partial mesorectal excision (PME) for proximal cancer, when a 4- to 5-cm mesorectal margin could be achieved. Risk factors for local recurrence and survival were also analyzed. ⋯ Anterior resection with mesorectal excision is a safe option and can be performed in the majority of patients with rectal cancer. The local recurrence rate was 9.7% and the cancer-specific survival was 74.5%. When the tumor requires a TME, this procedure is more complex and has a higher leakage rate than in those higher tumors where PME provides adequate mesorectal clearance. By performing TME in patients with mid and distal rectal cancer, the local control and survival of these patients are similar to those of patients with proximal cancers where adequate clearance can be achieved by PME.