Annals of surgery
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Comparative Study
Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients.
This study aims to review the operative results and oncological outcomes of anterior resection for rectal and rectosigmoid cancer. Comparison was made between patients with total mesorectal excision (TME) for mid and distal cancer and partial mesorectal excision (PME) for proximal cancer, when a 4- to 5-cm mesorectal margin could be achieved. Risk factors for local recurrence and survival were also analyzed. ⋯ Anterior resection with mesorectal excision is a safe option and can be performed in the majority of patients with rectal cancer. The local recurrence rate was 9.7% and the cancer-specific survival was 74.5%. When the tumor requires a TME, this procedure is more complex and has a higher leakage rate than in those higher tumors where PME provides adequate mesorectal clearance. By performing TME in patients with mid and distal rectal cancer, the local control and survival of these patients are similar to those of patients with proximal cancers where adequate clearance can be achieved by PME.
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Comparative Study
Paradoxical effect of IL-18 therapy on the severe and mild Escherichia coli infections in burn-injured mice.
To investigate the effects of IL-18 therapy on severe and mild bacterial infection after burn injury. ⋯ IL-18 therapy can be a potent therapeutic tool against severe bacterial infection in immunocompromised hosts, but careful attention should also be paid to its adverse effects.
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Comment Letter Comparative Study
Laparoscopic adjustable silicone gastric banding versus vertical banded gastroplasty in morbidly obese patients.