Annals of surgery
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To develop an animal model of injury that more closely represents the human inflammatory cell response to injury. ⋯ These experiments are the first to demonstrate the suitability of humanized mice for injury research. They offer the possibility to address very specific research questions that are not amenable to traditional mouse models of injury, for example, the emerging role of certain human-specific genes that are either unrepresented or totally absent, from the mouse genome.