Annals of surgery
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To determine the physiologic importance of endocannabinoids and mitochondrial function in the long-term outcome using a rat model of Roux-en-Y gastric bypass (RYGB) surgery. ⋯ The attenuated caloric intake, reduced food efficiency, and normalization of hormonal levels on day 28 post-RYGB were associated with significant down-regulation of endocannabinoids anandamide and 2-arachidonoylglycerol in muscle and liver, respectively. These results suggest a role for endocannabinoids in the mechanism of sustained weight loss and RYGB success, and may have implications for treatment of morbid obesity.
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To estimate the importance of center and provider effect and its implication on the estimation of treatment effect in surgical randomized controlled trials. ⋯ Provider and center effects play a significant role in the estimation of treatment effect of large randomized controlled surgical trials. Not accounting for such effects may lead to biased estimates and misleading conclusions. These effects should be accounted for in the design and analysis of such trials.
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Review Meta Analysis
Continuous positive airway pressure for treatment of respiratory complications after abdominal surgery: a systematic review and meta-analysis.
We evaluated the potential benefit of continuous positive airway pressure (CPAP) to prevent postoperative pulmonary complications (PPCs), atelectasis, pneumonia, and intubation in patients undergoing major abdominal surgery. ⋯ This systematic review suggests that CPAP decreases the risk of PPCs, atelectasis, and pneumonia and supports its clinical use in patients undergoing abdominal surgery.
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We analyze, on a nationwide basis, the risk of re-reoperation with reference to previous inguinal hernia repair technique. ⋯ Laparoscopic repair is recommended for reoperation of a recurrence after primary open Lichtenstein repair.