Medical science monitor : international medical journal of experimental and clinical research
-
Review
Facial transplantation: understanding the interests of patients and hurdles to informed consent.
Facial transplantation for persons with severe facial deformity has sparked much debate in the bioethics community. Unfortunately, the primary ethical issues stemming from facial transplantation have been neglected in the flurry of published literature, resulting in a lopsided and inadequate evaluation of the interests of patients and our responsibilities to them. In this essay, I shall address the major concerns raised by those who believe that it would be unethical to allow persons with disfigured faces to undergo facial transplantation. ⋯ I shall demonstrate that this judgment is misguided and that patients can be sufficiently educated about the procedure's seemingly unique potential risks and benefits. Upon proving the hurdles to providing informed consent are surmountable, I shall establish that the worries held by opponents of facial transplantation do not justify withholding this procedure from disfigured persons. I shall explain that there is sufficient understanding of the possible outcomes of facial transplantation to ensure that the interests of patients will be given proper consideration, and that given our concern for the autonomy and well-being of patients, facial transplantation should be made available to suitable persons with drastic facial deformity.
-
Burn injuries in Iran, like in other developing countries, are much more common than in the USA and Europe. Although there are a few articles dealing with epidemiological studies of burn injuries in Iran, investigations regarding the quality of burn care are scant. This study was undertaken to determine current survival statistics and lengths of stay in the population of burned patients treated at two university burn units in Shiraz, Iran, during four years. ⋯ The resulting figures are terrifying and dreadful compared with those of developed countries. It is necessary to reevaluate treatment policies and modify, improve, and update the organization of our burn units.
-
Review
Targeting antioxidants to mitochondria and cardiovascular diseases: the effects of mitoquinone.
Mitochondria have long been known to play a critical role in maintaining the bioenergetic status of cells under physiological conditions. Mitochondria produce large amounts of free radicals, and mitochondrial oxidative damage can contribute to a range of degenerative conditions including cardiovascular diseases (CVDs). Although the molecular mechanisms responsible for mitochondrion-mediated disease processes are not correctly understood, oxidative stress seems to play an important role. ⋯ These mitochondrion-targeted antioxidants have been developed by conjugating the lipophilic triphenylphosphonium cation to antioxidant moieties such as ubiquinol. These compounds pass easily through biological membranes and, due to their positive charge, they accumulate several-hundred-fold within mitochondria. In this way they protect against mitochondrial oxidative damage and show potential as a future therapy for CVDs.
-
Review
Pooled analysis of 857 published adult fever of unknown origin cases in Turkey between 1990-2006.
The aim of this study was a systematic review of the literature related to adult fever of unknown origin (FUO) in Turkey. ⋯ Tuberculosis and brucellosis remain common causes of FUO in Turkey. In addition, lymphomas and adult-onset Still's disease should be considered in the differential diagnosis of a patient admitted with FUO.
-
Empathy is the backbone of a positive physician-patient relationship. Physician empathy and the patient's awareness of the physician's empathic concern can lead to a more positive clinical outcome. ⋯ These findings provide further support for the validity of the JSPE. Implications for the assessments of empathy in the physician-patient relationship as related to clinical outcomes are discussed.