Respirology : official journal of the Asian Pacific Society of Respirology
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy and safety of indacaterol 150 and 300 µg in chronic obstructive pulmonary disease patients from six Asian areas including Japan: a 12-week, placebo-controlled study.
The efficacy and safety of indacaterol, a novel inhaled once daily ultra long-acting β(2) -agonist was evaluated in COPD patients in six Asian countries/areas. This study was primarily designed to obtain the regulatory approval of indacaterol in Japan. ⋯ Indacaterol provided clinically significant bronchodilation and improvements in dyspnoea and health status in Asian COPD patients.
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Comparative Study
Investigation of the urge-to-cough sensation in healthy volunteers.
Recently, there has been interest in the sensation of irritation that precedes the motor act of coughing, which has been termed the urge-to-cough (UTC). The aim of this study was to perform the largest evaluation to date of the UTC threshold (C(u)) in a healthy population. The specific aims were to investigate the relationship between C(u) and cough reflex sensitivity, to evaluate gender differences in the UTC and to assess the reproducibility of measurements of C(u). ⋯ These results demonstrate that the UTC threshold can be effectively and reproducibly measured using a modification of standard cough challenge methodology. Given its clinical significance as a prevalent symptom, UTC, as measured by C(u), represents an additional relevant end point for studies investigating the effects of pharmacological and other interventions in cough and cough reflex sensitivity.