Respirology : official journal of the Asian Pacific Society of Respirology
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Randomized Controlled Trial
Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis.
To explore the effect of long-term therapy with azithromycin in regards to airway oxidative stress markers in exhaled breath condensate (EBC) of adult patients with stable non-cystic fibrosis (CF) bronchiectasis. ⋯ Long-term azythromicin treatment has some clinical benefits in patients with non-CF stable bronchiectasis, but it does not affect airway oxidative stress markers.
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Comparative Study
Comparing finger and forehead sensors to measure oxygen saturation in people with chronic obstructive pulmonary disease.
Oxyhaemoglobin saturation of arterial blood is commonly measured using a finger sensor attached to a pulse oximeter (SpO(2)). We sought to compare SpO(2) measured using finger and forehead sensors with oxyhaemoglobin saturation in arterialized capillary samples (ACS) in people with chronic obstructive pulmonary disease (COPD) during exercise. ⋯ Oxygen saturation measured using the forehead sensor was higher than that measured in ACS. Assuming that oxygen saturation in ACS is slightly less than arterial blood, forehead sensors may yield measures more concordant with arterial blood. Both sensors detected exercise-induced desaturation.
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Oxidative stress resulting from tobacco smoking has been suggested to play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to evaluate the oxidant and antioxidant levels in smokers with and without COPD. ⋯ Our study demonstrates that there is an oxidant antioxidant imbalance in COPD patients and suggests the importance of GPx in maintaining lung function.