Archives of disease in childhood
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To determine the prevalence and predictors of microalbuminuria (MA) (urine albumin-creatinine ratios (ACRs) of 30-300 µg/mg) in children with homozygous sickle cell (Hb SS) disease in Jamaica. ⋯ MA is seen as early as 2.8 years in children with sickle cell disease. Risk factors for MA include glomerular hyperfiltration, nutritional factors and vaso-occlusion but not haemolysis. Interventions addressing these factors may be useful.
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Randomized Controlled Trial Comparative Study
Medicine dosing by weight in the home: can parents accurately weigh preschool children? A method comparison study.
To determine the accuracy with which parents can estimate preschool children's weight using home scales in order to calculate antipyretic dose. ⋯ Weight can be estimated accurately enough to calculate antipyretic medicine doses by the minority of parents having scales that can be used to estimate their child's weight.
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Multicenter Study
Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey.
To characterise current hospital practice and use of prescribing resources related to drug treatment for low cardiac output syndrome (LCOS) in children with open heart surgery (OHS) in Europe. ⋯ Drug treatment for LCOS in children with OHS across Europe is highly variable, possibly partly reflecting the lack of evidence and prescribing standards on the use of medicines. Milrinone, epinephrine, dopamine and dobutamine are mostly used, and should be prioritised for future research on LCOS treatment. Such research should be aimed at increasing the level of evidence for clinical practice guidelines to improve the standard of care.
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Review Meta Analysis
Neuroimaging: what neuroradiological features distinguish abusive from non-abusive head trauma? A systematic review.
To identify the evidence base behind the neuroradiological features that differentiate abusive head trauma (AHT) from non-abusive head trauma (nAHT). ⋯ Multiple SDH over the convexity, interhemispheric haemorrhages, posterior fossa SDH, HII and cerebral oedema are significantly associated with AHT and should be considered together with clinical features when identifying the condition.
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Review Comparative Study
Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone.
To evaluate the evidence surrounding the use of combinations of paracetamol and ibuprofen in the treatment of fever. ⋯ There is little evidence of any benefit or harm from the combined treatment compared with the use of each drug alone. In the absence of such benefit, there is little to recommend the unnecessary use of polypharmaceutical methods to treat a symptom that does not require treatment, when effective monotherapies exist.