Clinical journal of oncology nursing
-
Although vincristine sulfate is indicated for IV use only, it has been inadvertently administered intrathecally. Accidental vincristine administration via the spinal route (intrathecally via a lumbar puncture or intraventricularly via an Ommaya reservoir) causes rapid sensory and motor dysfunction, usually followed by encephalopathy, coma, and death (Schulmeister, 2004). Autopsy findings include grossly edematous and congested brain and spinal cord tissue, with axonal degeneration and myelin loss of the spinal nerves (Kwack et al., 1999; Williams et al., 1983).
-
Review Case Reports
The ethical dilemma of medical futility: the case of Mr. X.
-
Presently, healthcare providers have little scientific evidence on which to base recommendations about use of herbal supplements with chemotherapy. Lack of product standardization and definitive knowledge about herb interaction with chemotherapy may expose patients with cancer to potentially serious side effects. Patients continue to use herbal supplements with their cancer treatments, often without informing their healthcare providers. Research currently is ongoing to study the effects of the concomitant administration of herbal supplements and chemotherapy.