CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Meta Analysis Comparative Study
Relation between randomized controlled trials published in leading general medical journals and the global burden of disease.
More than two-thirds of the world's population live in low-income countries, where health priorities are different from those of people living in more affluent parts of the world. We evaluated the relation between the global burden of disease and conditions or diseases studied in randomized controlled trials (RCTs) published in general medical journals. ⋯ Many conditions or diseases common internationally are underrepresented in RCTs published in leading general medical journals. Trials published in these journals that studied one of these high-priority conditions were generally rated as being of little relevance to international health.
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Randomized Controlled Trial Multicenter Study Clinical Trial
The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada.
Research into adverse events (AEs) has highlighted the need to improve patient safety. AEs are unintended injuries or complications resulting in death, disability or prolonged hospital stay that arise from health care management. We estimated the incidence of AEs among patients in Canadian acute care hospitals. ⋯ The overall incidence rate of AEs of 7.5% in our study suggests that, of the almost 2.5 million annual hospital admissions in Canada similar to the type studied, about 185 000 are associated with an AE and close to 70 000 of these are potentially preventable.