British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Neuromuscular block by suxamethonium following treatment with histamine type 2 antagonists or metoclopramide.
We have examined the effect of preoperative i.v. administration of three different histamine type 2 (H2) antagonists (cimetidine 400 mg, ranitidine 80 mg and famotidine 20 mg) or metoclopramide 10 mg i.v. on the duration of neuromuscular block produced by an intubating dose (1 mg kg-1) of suxamethonium. The study was conducted blindly in 70 post partum patients, weighing between 45 and 120 kg, scheduled for tubal ligation. ⋯ The time from onset of 95% block to 25% recovery ("block time") was not significantly different between the groups receiving cimetidine (A), ranitidine (B), famotidine (C), and control (E). However, there was prolongation of neuromuscular block in patients receiving suxamethonium and metoclopramide (D).
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Randomized Controlled Trial Comparative Study Clinical Trial
Pressor and catecholamine response to nasal intubation of the trachea.
The catecholamine and cardiovascular responses to nasal intubation of the trachea with and without laryngoscopy have been compared in 23 patients allocated randomly to each treatment. Arterial pressure, heart rate and plasma concentrations of adrenaline and noradrenaline were measured before and after induction and at 1, 3 and 5 min after intubation of the trachea. There were significant increases in systolic and diastolic pressures after tracheal intubation in both groups. The values at 1 min after intubation were significantly higher in the group undergoing laryngoscopy and intubation compared with the group undergoing blind nasal intubation.