British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Ease of placement of the laryngeal mask during manual in-line neck stabilization.
We studied 20 patients, in a randomized, cross-over study, to determine if manual in-line stabilization of the head and neck altered the ease of insertion of the laryngeal mask and its correct positioning. After induction of anaesthesia and neuromuscular block, the laryngeal mask was inserted and adequacy of ventilation assessed while the patient's head and neck were placed in the Magill and manual in-line positions, in turn. Ease of insertion of the mask was assessed using a 10-cm visual analogue scale (VAS) and position using a fibreoptic bronchoscope. ⋯ Insertion was always more difficult (P < 0.001; 95% CI for difference in VAS 20-55 mm) and time for insertion longer (P < 0.001; 95% CI for difference 4.9-11.9 s) in the manual in-line position compared with the Magill position. The incidence of a suboptimal position was significantly higher for the manual in-line position (seven patients) than for the Magill position (15 patients) (P < 0.005). We conclude that in paralysed patients, manual in-line stabilization of the head and neck made insertion of the laryngeal mask and its correct positioning more difficult.
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The upper airway abnormalities predisposing to difficult tracheal intubation may also predispose to obstructive sleep apnoea (OSA). The potential association is important as both conditions increase perioperative risk and patients with a trachea that is difficult to intubate may need assessment for OSA. We determined if patients with difficult intubation are at greater risk of OSA and, if so, whether or not they have characteristic clinical or radiographic upper airway changes. ⋯ We conclude that difficult intubation and OSA are related significantly. They share anatomical features which act to reduce the skeletal confines of the tongue. Patients with OSA may compensate, when awake, by increasing craniocervical angulation, which increases the space between the mandible and cervical spine and elongates the tongue and soft tissues of the neck.
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Respiratory failure following cardiopulmonary bypass (CPB) is a major complication after cardiac surgery. A vital capacity inflation of the lungs, performed before the end of CPB, may improve gas exchange, but the necessity to repeat it is unclear. Therefore, we studied 18 pigs undergoing hypothermic CPB. ⋯ From 3 to 6 h after CPB, there was no more improvement and more than 10% atelectasis remained at 6 h. In contrast, the two groups treated before termination of CPB with VCM showed only minor atelectasis and no abnormal changes in gas exchange directly after bypass or later. We conclude that the protective effect of VCM remained for 6 h after bypass, and there was no extra benefit on gas exchange by repeating the VCM.
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Biography Historical Article Classical Article
Anaesthesia for caesarean section. 1970.
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Randomized Controlled Trial Clinical Trial
Interaction of a subanaesthetic concentration of isoflurane with midazolam: effects on responsiveness, learning and memory.
There are situations in which "light" anaesthesia combined with neuromuscular block is the only anaesthetic regimen that can be tolerated safely by the patient. Benzodiazepines have hypnotic and specific amnesic effects. Therefore, we have examined the interaction of midazolam with a subanaesthetic dose of isoflurane (0.2% end-expired concentration) in 28 healthy volunteers. ⋯ Recognition was also absent after administration of midazolam 0.06 mg kg-1 and at the 3-min and 15-min assessments after administration of midazolam 0.03 mg kg-1. Responsiveness was more frequent with midazolam 0.03 mg kg-1 than with 0.06 mg kg-1 and increased over time. We conclude that a larger dose of midazolam or isoflurane, or both, may be necessary to abolish responsiveness.