British journal of anaesthesia
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Diaspirin cross-linked haemoglobin (DCLHb) is a new oxygen carrying blood substitute with vasoactive properties. Vasoactive properties may be mediated via high affinity binding of nitric oxide by the haem moiety. Using a rodent model of head injury combined with ischaemia, we studied the effects of DCLHb on cerebral blood flow (CBF) and intracranial pressure (ICP). ⋯ Mean arterial pressure (MAP), ICP, cerebral perfusion pressure (CPP) (CPP = MAP - ICP) and CBF were measured 4 h after injury in all animals. DCLHb significantly reduced ICP from mean 13 (SEM 2) to 3 (1) mm Hg (P < 0.001), increased CPP from 52 (8) to 95 (6) mm Hg (P < 0.001) and increased CBF from 21 (2) to 29 (2) ml 100 g-1 min-1 (P = 0.032). We conclude that DCLHb improved CPP without a reduction in CBF in a rodent model of post-traumatic brain swelling.
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We studied six operating department assistants performing simulated cricoid pressure on a model of the larynx with the arm either flexed to 90 degrees (flexed position) or fully extended with the elbow locked (extended position). Subjects were asked to maintain forces of 20, 30 and 40 Newtons (N) for a target time of 20 min. Subjects rated pain during each assessment on a four-point verbal rating scale (VRS): 1 = uncomfortable; 2 = hurting; 3 = hurting a lot; and 4 = agony. ⋯ Mean times to release at 20 N were: flexed position (four subjects) 13.2 min, extended position (one subject) 14.6 min. Use of the extended arm consistently prolonged times to pain and fatigue. These findings are relevant to the management of cricoid pressure during failed intubation.