British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Analgesic effects of parecoxib following total abdominal hysterectomy.
Forty-eight ASA I-II patients undergoing total abdominal hysterectomy (TAH) were studied in a double blind, randomized placebo controlled trial of parecoxib for postoperative analgesia. ⋯ Parecoxib 40 mg i.v. may be recommended in patients having TAH as it provides morphine-sparing analgesia.
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Randomized Controlled Trial Clinical Trial
Sedation caused by clonidine in patients with spinal cord injury.
In patients with spinal cord injury, cephalad spread of intrathecal (i.t.) medication could be delayed. ⋯ A systemic effect is likely to be the main reason for sedation.
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In a previous study we used the bispectral index (BIS) for automatic control of propofol anaesthesia, using a proportional-integral-differential control algorithm. As control was less than optimal in some patients, we revised the constants of the control algorithm. The aim of the current study was to measure the performance of the revised system in patients undergoing minor surgery under propofol and remifentanil anaesthesia. ⋯ The system was able to provide clinically adequate anaesthesia in all patients, with better accuracy of control than in the previous study. There was a tendency for more accurate control in those patients in whom the control algorithm incorporated effect-site steering.