British journal of anaesthesia
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Dexmedetomidine, a sedative agent, provides neuroprotection when administered during or before brain ischaemia. This study was designed to determine whether dexmedetomidine post-treatment induces neuroprotection against subarachnoid haemorrhage (SAH) and the mechanisms for this effect. ⋯ Dexmedetomidine post-treatment provides neuroprotection against SAH. This effect appears to be mediated by ERK.