British journal of anaesthesia
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Observational Study
Norepinephrine exerts an inotropic effect during the early phase of human septic shock.
We conducted this study to investigate whether norepinephrine increases cardiac contractility when administered during the early phase of septic shock. ⋯ NCT02750683.
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We tested the primary hypothesis that corticosteroid administration after etomidate exposure reduces a composite of in-hospital mortality and cardiovascular morbidity after non-cardiac surgery. ⋯ Steroid administration after induction of anaesthesia with etomidate did not reduce mortality or cardiovascular morbidity.
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Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model. ⋯ Co-exposure to IR and ketamine can aggravate developmental neurotoxic effects at doses where the single agent exposure does not impact on the measured variables. These findings show that estimation of risk after paediatric low-dose IR exposure, based upon radiation dose alone, may underestimate the consequences for this vulnerable population.