British journal of anaesthesia
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Randomized Controlled Trial Comparative Study
Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults.
The choice of general anaesthetics may affect postoperative cognitive outcomes. This study was designed to compare the potential impact of propofol-based vs sevoflurane-based general anaesthesia on the development of delayed neurocognitive recovery in older adults early after major cancer surgery. ⋯ NCT02662257; Chinese Clinical Trial Registry (identifier: ChiCTR-IPR-15006209).
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Randomized Controlled Trial
Randomised controlled trial comparing preoperative carbohydrate loading with standard fasting in paediatric anaesthesia.
Preoperative fasting is a major cause of perioperative discomfort in paediatric anaesthesia and leads to postoperative insulin resistance, thus potentially enhancing the inflammatory response to surgery. Addressing these problems by preoperative carbohydrate intake has not been a well-defined approach in children. ⋯ DRKS00005020.
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Multicenter Study
Conditioned pain modulation identifies altered sensitivity in extremely preterm young adult males and females.
Conditioned pain modulation is a potential biomarker for risk of persistent pain. As early-life experience can alter subsequent somatosensory processing and pain response, we evaluated conditioned pain modulation after extremely preterm birth. ⋯ Cold conditioning evoked inhibitory modulation in the majority of young adults and identified a subgroup of extremely preterm females with increased baseline sensitivity. Early-life experience and sex/gender should be considered when evaluating persistent pain risk with conditioned pain modulation.
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Clinical Trial
Population pharmacokinetic analysis of propofol in underweight patients under general anaesthesia.
The modified Marsh and Schnider pharmacokinetic models for propofol consistently produce negatively and positively biased predictions in underweight patients, respectively. We aimed to develop a new pharmacokinetic model of propofol in underweight patients. ⋯ KCT0001760.
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Comparative Study
Estimating the rapid haemodynamic effects of passive leg raising in critically ill patients using bioreactance.
Rapid detection of changes in cardiac index (CI) in real time using minimally invasive monitors may be of clinical benefit. We tested whether the Starling-SV bioreactance device, which averages CI over a short 8 s period, could assess the effects of passive leg raising (PLR), a clinical test that is recommended to assess fluid responsiveness during septic shock. ⋯ In critically ill patients, a non-invasive bioreactance device with a shorter averaging period assessed a passive leg raising test with reasonable accuracy.