British journal of anaesthesia
-
Standardising nomenclature facilitates diagnostic and therapeutic algorithms, improves comparisons of data in scientific research and reduces misunderstanding. Here, we propose a nomenclature for suspected perioperative allergic reactions.
-
Macrophage phagocytosis constitutes an essential part of the host defence against microbes and the resolution of inflammation. Hyperglycaemia during sepsis is reported to reduce macrophage function, and thus, potentiate inflammatory deterioration. We investigated whether high-glucose concentrations augment lipopolysaccharide-induced reduction in macrophage phagocytosis via the endoplasmic stress-C/EBP homologous protein (CHOP) pathway using animal and laboratory investigations. ⋯ These findings imply that controlling endoplasmic reticulum stress might provide new strategies for restoring reduced macrophage phagocytosis in sepsis-induced hyperglycaemia.