British journal of anaesthesia
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Traditional formulas to calculate pulse pressure variation (PPV) cannot be used in patients with atrial fibrillation (AF). We have developed a new algorithm that accounts for arrhythmia-induced pulse pressure changes, allowing us to isolate and quantify ventilation-induced pulse pressure variation (VPPV). The robustness of the algorithm was tested in patients subjected to altered loading conditions. We investigated whether changes in VPPV imposed by passive leg raising (PLR) were proportional to the pre-PLR values. ⋯ Our algorithm enables quantification of VPPV in patients with AF with the ability to detect changing loading conditions.
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Letter Observational Study
Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome.
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Multicenter Study
Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial.
Intravenous tranexamic acid (TXA) reduces bleeding deaths after injury and childbirth. It is most effective when given early. In many countries, pre-hospital care is provided by people who cannot give i.v. injections. We examined the pharmacokinetics of intramuscular TXA in bleeding trauma patients. ⋯ 2019-000898-23 (EudraCT); NCT03875937 (ClinicalTrials.gov).