British journal of anaesthesia
-
Randomized Controlled Trial Multicenter Study
Local infiltration of HYR-PB21, a sustained-release formulation of bupivacaine, provides analgesia and reduces opioid requirement after haemorrhoidectomy: a randomised controlled trial.
HYR-PB21 is a new sustained-release formulation of bupivacaine indicated for controlling postoperative pain. The objectives of this study were to investigate the analgesic efficacy and safety profile of HYR-PB21 in patients after haemorrhoidectomy. ⋯ ChiCTR2000041318 (Chinese Clinical Trial Registry).
-
Review Meta Analysis
Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis.
Preemptive analgesia may improve postoperative pain management, but the optimal regimen is unclear. This study aimed to compare the effects and adverse events of preemptive analgesia on postoperative pain and opioid consumption. ⋯ PROSPERO CRD42021232593.
-
Review Meta Analysis
Pre-hospital tracheal intubation in severe traumatic brain injury: a systematic review and meta-analysis.
Severe traumatic brain injury (TBI) continues to be a leading cause of death, particularly in young adults. Severe TBI contributes to significant socioeconomic burden secondary to the long-term disability, impacting the individual and their family, and wider society. The aim of this study was to determine whether establishing a pre-hospital definitive airway was beneficial to mortality and morbidity when compared with no pre-hospital airway. ⋯ CRD42021234439.