British journal of anaesthesia
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Observational Study
Ventilatory ratio, dead space, and venous admixture in acute respiratory distress syndrome.
Ventilatory ratio (VR) has been proposed as an alternative approach to estimate physiological dead space. However, the absolute value of VR, at constant dead space, might be affected by venous admixture and CO2 volume expired per minute (VCO2). ⋯ VR is a useful aggregate variable associated with outcome, but variables not associated with ventilation (VCO2 and venous admixture) strongly contribute to the high values of VR seen in patients with severe illness.
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Randomized Controlled Trial
High-dose steroid in low pain responders undergoing total knee arthroplasty: a randomised double-blind trial.
Postoperative pain after total knee arthroplasty (TKA) is a continuing problem despite optimised multimodal analgesia. Previous studies have shown preoperative glucocorticoids to reduce postoperative pain, but knowledge about specific doses and effects in specific patient groups is lacking. ⋯ NCT03758170 (first registration 29-11-2018).
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Perioperative frailty is prevalent and requires complex management, which could be guided by clinical practice guidelines (CPGs). The objective of this systematic review was to identify and synthesise CPGs that provide perioperative recommendations specific to older adults living with frailty. ⋯ PROSPERO CRD42022320149.