British journal of anaesthesia
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Randomized Controlled Trial
Effect of machine learning models on clinician prediction of postoperative complications: the Perioperative ORACLE randomised clinical trial.
Anaesthesiologists might be able to mitigate risk if they know which patients are at greatest risk for postoperative complications. This trial examined the impact of machine learning models on clinician risk assessment. ⋯ NCT05042804.
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Higher inspired oxygen fraction during one-lung ventilation is not independently associated with postoperative pulmonary complications.
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Multicenter Study
Characterisation of older patients that require, but do not undergo, emergency laparotomy: a multicentre cohort study.
Older adults (≥65 yr) account for the majority of emergency laparotomies in the UK and are well characterised with reported outcomes. In contrast, there is limited knowledge on those patients that require emergency laparotomy but do not undergo surgery (NoLaps). ⋯ ISRCTN14556210.
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There is a lack of qualitative data on the negative effects of workplace stressors on the well-being of healthcare professionals in hospitals in Africa. It is unclear how well research methods developed for high-income country contexts apply to different cultural, social, and economic contexts in the global south. ⋯ The Rwandan healthcare system presents many challenges which can become profoundly stressful for the workforce. Consideration of reduced personal and collective accomplishment, of moral injury, and its diverse downstream effects on the whole healthcare system may better represent the costs of burnout Rwanda. It is likely that improving the causes of work-based stress will require a significant investment in improving staffing and working conditions.
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Analgesia is an important effect of volatile anaesthetics, for which the spinal cord is a critical neural target. However, how supraspinal mechanisms modulate analgesic potency of volatile anaesthetics is not clear. We investigated the contribution of the central amygdala (CeA) to the analgesic effects of isoflurane and sevoflurane. ⋯ The analgesic potencies of volatile anaesthetics are partially mediated by modulation of NALCN in CeAGABA neurones.