British journal of anaesthesia
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Analgesia is an important effect of volatile anaesthetics, for which the spinal cord is a critical neural target. However, how supraspinal mechanisms modulate analgesic potency of volatile anaesthetics is not clear. We investigated the contribution of the central amygdala (CeA) to the analgesic effects of isoflurane and sevoflurane. ⋯ The analgesic potencies of volatile anaesthetics are partially mediated by modulation of NALCN in CeAGABA neurones.
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Multicenter Study
Characterisation of older patients that require, but do not undergo, emergency laparotomy: a multicentre cohort study.
Older adults (≥65 yr) account for the majority of emergency laparotomies in the UK and are well characterised with reported outcomes. In contrast, there is limited knowledge on those patients that require emergency laparotomy but do not undergo surgery (NoLaps). ⋯ ISRCTN14556210.