British journal of anaesthesia
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Multicenter Study Observational Study
Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study.
Delirium is a frequent complication after surgery in older adults and is associated with an increased risk of long-term cognitive impairment and dementia. Disturbances in functional brain networks were previously reported during delirium. We hypothesised that alterations in functional brain networks persist after remission of postoperative delirium and that functional brain network alterations are associated with long-term cognitive impairment. ⋯ NCT02265263.
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Randomized Controlled Trial
Thromboelastometry-guided treatment algorithm in postpartum haemorrhage: a randomised, controlled pilot trial.
Postpartum haemorrhage causes significant mortality among parturients. Early transfusion of blood products based on clinical judgement and conventional coagulation testing has been adapted to the treatment of postpartum haemorrhage, but rotational thromboelastometry (ROTEM) may provide clinicians means for a goal-directed therapy to control coagulation. We conducted a parallel design, randomised, controlled trial comparing these two approaches. We hypothesised that a ROTEM-guided protocol would decrease the need for red blood cell transfusion. ⋯ NCT02461251.