British journal of anaesthesia
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It is unclear whether the innate immune response represents a therapeutic target for organ protection strategies in cardiac surgery. ⋯ The certainty of the evidence for a causal relationship between innate immune system activation and organ injury after cardiac surgery is low.
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Review Meta Analysis
Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis.
Postoperative delirium has eluded attempts to define its complex aetiology and describe specific risk factors. The role of neuroinflammation as a risk factor, determined by measuring blood levels of preoperative 'innate' inflammatory mediator levels, has been investigated. However, results have been conflicting. We conducted a systematic review and meta-analysis of the evidence on associations between preoperative blood levels of inflammatory mediators and postoperative delirium in the older person. Influence of type of surgery was also assessed. ⋯ CRD42019159471 (PROSPERO).
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Review Meta Analysis
Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis.
Preoperative lymphopaenia is associated with increased postoperative mortality and morbidity.
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Review Meta Analysis Comparative Study
Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis.
Control-arm mortality varies between acute respiratory distress syndrome (ARDS) RCTs. ⋯ In most ARDS RCTs, consensus definitions are modified to use as inclusion criteria. Between-RCT mortality differences are mostly explained by the Pao2:FiO2 ratio threshold within the consensus definitions. An exclusion criteria framework can be applied when designing and reporting exclusion criteria in future ARDS RCTs.
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Review Meta Analysis
Effects of general anaesthesia during pregnancy on neurocognitive development of the fetus: a systematic review and meta-analysis.
The US Food and Drug Administration warned that exposure of pregnant women to general anaesthetics may impair fetal brain development. This review systematically evaluates the evidence underlying this warning. ⋯ CRD42018115194.