British journal of anaesthesia
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Review Clinical Trial
Investigations on isoflurane, sevoflurane and other experimental anaesthetics.
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The adverse reactions to i.v. anaesthetics which occurred during a 3-yr period in one hospital were investigated. Sixteen reactions were reported; 13 of these occurred in a total of 7906 administrations of Althesin, two in 45 546 administrations of thiopentone and one in 630 administrations of methohexitone. The pathological process was identified in 10 patients. Most reactions were caused by activation of the alternate pathway for complement conversion.
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The effect of halothane on the respiratory pattern was investigated in lightly anaesthetized cats. Following the administration of 2.0% halothane there was a transient increase in respiratory frequency because of a decrease in the duration of expiration, followed by a progressive decrease in respiratory frequency as a result of prolongation of inspiration; both events could be demonstrated before and after vagotomy. ⋯ Tidal phrenic output decreased progressively as the concentration of halothane was increased. These results suggest that changes in respiratory pattern seen during halothane anaesthesia might involve some excitatory central mechanisms other than the bulbopontine system.