British journal of anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Nefopam in postoperative pain.
Three comparable groups of surgical patients were given nefopam 0.2 mg kg-1 or 0.4 mg kg-1 or morphine 0.15 mg kg-1 for pain relief after operation. Nefopam 0.4 mg kg-1 was equi-analgesic with morphine 0.15 mg kg-1 and produced no obvious cardiovascular or respiratory side-effects.
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Clinical Trial Controlled Clinical Trial
Effect of Diazepam at the neuromuscular junction. A clinical study.
In patients undergoing surgery under general anaesthesia diazepam 0.16 mg kg-1 had no effect on mechanical twitch height of the adductor pollicis muscle of the thumb when the ulnar nerve was stimulated at the wrist. The muscle responses were evoked by single, repeated supramaximal stimuli at 0.2 Hz and "train-of-four" stimulation at 2 Hz for 2 s. Diazepam 0.16 mg kg-1 had no effect on the depth or recovery of neuromuscular blockade produced by suxamethonium, tubocurarine, pancuronium, fazadinium or alcuronium.
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Randomized Controlled Trial Comparative Study Clinical Trial
Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.
In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. ⋯ No relationship to dose rate of nitroprusside was found with these short-term infusions. It is concluded that sodium nitroprusside can be used safely for induced hypotension at doses less than 1.5 mg kg-1 and that simple blood-gas analysis is adequate for the assessment of toxic effects when greater doses are given.
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A simple apparatus and a method are described by which an exact end-point can be attained in inflating the bronchial cuff of a double-lumen tube, and accidental collapse of the cuff detected.
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Letter Case Reports
Fire and explosion hazards in operating theatres: a reply and new evidence.