British journal of anaesthesia
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The use of a halothane meter in routine paediatric anaesthesia with controlled ventilation is described. The results demonstrate the accuracy achieved in the control of the alveolar halothane concentration. Measurement of the alveolar halothane concentration revealed responses to surgical stimulation otherwise obscured by neuromuscular blockade, and this may indicate insufficient depth of anaesthesia.
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Letter Case Reports
Fire and explosion hazards in operating theatres: a reply and new evidence.
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Randomized Controlled Trial Comparative Study Clinical Trial
Metabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.
In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. ⋯ No relationship to dose rate of nitroprusside was found with these short-term infusions. It is concluded that sodium nitroprusside can be used safely for induced hypotension at doses less than 1.5 mg kg-1 and that simple blood-gas analysis is adequate for the assessment of toxic effects when greater doses are given.
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The cardiovascular effects of infusions of Althesin at various rates to supplement nitrous oxide anaesthesia have been studied in seven spontaneously breathing patients and11 patients ventilated artificially to normal PaCO2. During spontaneous breathing, increasing rates of Althesin infusion were associated with increases in heart rate and cardiac output. The modest decrease in arterial pressure (-5%) was the result of a decrease in vascular resistance. Increasing rates of Althesin rates of Althesin infusion (up to eight times the minimum infusion rate) caused dose-dependent decreases of arterial pressure and systemic vascular resistance, whereas heart rate and cardiac output were increased slightly at all rates of infusion.