British journal of anaesthesia
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Letter Observational Study
Gastric fluid volume in adults after implementation of a liberal fasting policy: a prospective cohort study.
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It is unclear whether the innate immune response represents a therapeutic target for organ protection strategies in cardiac surgery. ⋯ The certainty of the evidence for a causal relationship between innate immune system activation and organ injury after cardiac surgery is low.
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Review Meta Analysis
Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis.
Postoperative delirium has eluded attempts to define its complex aetiology and describe specific risk factors. The role of neuroinflammation as a risk factor, determined by measuring blood levels of preoperative 'innate' inflammatory mediator levels, has been investigated. However, results have been conflicting. We conducted a systematic review and meta-analysis of the evidence on associations between preoperative blood levels of inflammatory mediators and postoperative delirium in the older person. Influence of type of surgery was also assessed. ⋯ CRD42019159471 (PROSPERO).