British journal of anaesthesia
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Observational Study
Spinal anaesthesia for patients with coronavirus disease 2019 and possible transmission rates in anaesthetists: retrospective, single-centre, observational cohort study.
Spinal anaesthesia for Caesarean section in patients with COVID can be provided safely, although anaesthetists are at risk of infection, significantly reduced by use of Level 3 PPE (PAPR + protective suit).
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Early administration of the antifibrinolytic drug tranexamic acid reduces death from bleeding in trauma and postpartum haemorrhage. We examined how the effectiveness and safety of antifibrinolytic drugs varies by the baseline risk of death as a result of bleeding. ⋯ Tranexamic acid appears to be safe and effective regardless of baseline risk of death. Because many deaths are in patients at low and intermediate risk, tranexamic acid use should not be restricted to the most severely injured or bleeding patients.
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Randomized Controlled Trial
Sphenopalatine ganglion block for the treatment of postdural puncture headache: a randomised, blinded, clinical trial.
Current treatment of postdural puncture headache includes epidural blood patch (EBP), which is invasive and may result in rare but severe complications. Sphenopalatine ganglion block is suggested as a simple, minimally invasive treatment for postdural puncture headache. We aimed to investigate the analgesic effect of a transnasal sphenopalatine ganglion block with local anaesthetic vs saline. ⋯ NCT03652714.
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Randomized Controlled Trial
Remifentanil and perioperative glycaemic response in cardiac surgery: an open-label randomised trial.
This study investigated whether remifentanil infusion decreased intraoperative hyperglycaemia and insulin resistance compared with intermittent fentanyl administration in patients undergoing elective cardiac surgery. ⋯ NCT02349152.