International journal of clinical practice
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Int. J. Clin. Pract. · Sep 2020
The association between serum levels of growth differentiation factor-15 and activity of rheumatoid arthritis.
Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Growth differentiation factor-15 (GDF-15) acts as an autocrine regulator of macrophage activation. ⋯ GDF-15 serum levels may be used as a biomarker to predict high RA disease activity.
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Int. J. Clin. Pract. · Sep 2020
Clinimetric properties of the one leg sit to stand test in examining unilateral lower limb muscle strength among young adults.
One-leg sit-to-stand (one-leg STS) test is a new clinical test developed to measure the unilateral lower limb (LE) muscle strength among young adults. This study examined the test-retest reliability and the criterion-concurrent validity of the one-leg STS. ⋯ The one-leg STS test demonstrated excellent reliability and criterion-concurrent validity against the two-leg STS and the LE muscle strength. The one-leg STS test was simple to administer and could be beneficial for the assessment of unilateral LE muscle strength of young adults in clinical settings.
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Int. J. Clin. Pract. · Sep 2020
Synonymous polymorphism rs201256011 in Dopamine receptor type 2 gene is associated with schizophrenia and PANSS score in Pakistani population: A First Report.
Variations of dopamine receptor type 2 (DRD2) are among the key factors involved in the pathology of schizophrenia. Presence of certain SNPs in DRD2 gene also amend patients' response to antipsychotics. Keeping in view the genetic diversity among populations and important role of DRD2 polymorphisms in schizophrenia, we aimed to study two of its SNPs rs1801028 and rs6277 in patients with schizophrenia from Pakistan. ⋯ In conclusion, genetic variants rs1801028 and rs6277 of DRD2 are not associated with schizophrenia in Pakistani population. While, previously unreported polymorphism rs201256011 have shown significant association with schizophrenia and its severity. A large scale multicentre replication study is required to confirm the association of this SNP with schizophrenia.
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Int. J. Clin. Pract. · Sep 2020
Collaboration between cardiologist and clinical pharmacist on prescription quality: What is the potential clinical impact for cardiology patients?
The aim of this study was to determine the effect of pharmacists' interventions (PI) on the potential clinical impact of medication errors, including the lack of therapeutic optimisation of patients with cardiologic diseases, such as heart failure and acute coronary syndrome). ⋯ The collaboration between clinical pharmacists and cardiologists in the medical units seems to be beneficial to the quality of prescriptions, including the implementation of recommendations. The good rate of PI acceptance and the similar rating with the cardiologist show that there is a change in perspective of the pharmacist, being closer to the clinical reality.
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Int. J. Clin. Pract. · Sep 2020
Intravesical Prostatic Protrusion does not compromise therapeutic effects of Mirabegron in male patients with overactive bladder.
Intravesical prostatic protrusion (IPP) is associated with the degree of benign prostatic obstruction. We evaluated the effects of Mirabegron, a selective β3 adrenoceptor agonist, on overactive bladder (OAB) in male patients with different degrees of IPP. ⋯ Mirabegron is an effective drug to treat male OAB regardless of IPP grade.