International journal of clinical practice
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Int. J. Clin. Pract. · Oct 2021
Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signaling pathway in mice.
Pregnancy-induced hypertension (PIH) is characterized by high blood pressure during pregnancy, which causes perinatal and maternal mortality. Inflammation, oxidative stress and the JAK2/STAT3 signalling pathway have been reported to play critical roles in the pathogenies of PIH. Due to the safety and side effects of current treatments for PIH, searching for new therapeutic agents is urgently needed. Naringenin is a flavonoid with anti-inflammation and anti-oxidation activities. In the current study, the effects of naringenin on PIH were investigated. ⋯ Naringenin suppressed the activation of JAK2/STAT3 signalling pathway and promoted SHP-1 expression, leading to ameliorated hypertension in pregnancy.
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Int. J. Clin. Pract. · Oct 2021
Retracted PublicationWestern Pacific Consensus Proposals for Management of Prediabetes.
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Int. J. Clin. Pract. · Oct 2021
Review Meta AnalysisGlycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: meta-analysis of observational studies.
Diets with high glycemic index (GI) or high glycemic load (GL) have been linked to important risk factors associated with the development of metabolic syndrome (MetS), such as dyslipidemia, higher blood glucose, and insulin concentrations. However, the role of GI and GL in relation to Mets is still understudied and controversial. This review, therefore, assessed whether high GI or GL contribute to development of Mets. ⋯ A diet with lower GI may protect against MetS. Nutrition policy and clinical practices should encourage a diet with low GI. Future studies should include both GI and GL and different criteria of MetS to provide a better comparison.