International journal of clinical practice
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Int. J. Clin. Pract. · Jan 2021
The prevalence and patterns of self-medication with antibiotics in Jordan: A community-based study.
Self-medication with antibiotics is one of the leading causes of antibiotic resistance and drug therapy problems, making antibiotic self-medication practices a global concern. Despite global efforts to limit these practices, self-medication with antibiotics remains prevalent in developing countries. This study aimed to investigate the prevalence and patterns of self-medication with antibiotics in Jordan and to compare the findings of self-medication practices with antibiotics with results from 2006. ⋯ The findings of this study revealed that the prevalence of self-medication with antibiotics in Jordan remains high. This is a significant concern that requires a quick response from the government authorities to develop a collaborative approach to stop the dispensing of antibiotics without a prescription.
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Int. J. Clin. Pract. · Jan 2021
Knowledge, Attitude, Future Expectations, and Perceived Barriers of Medical Students and Physicians Regarding Pharmacogenomics in Jordan.
Pharmacogenomics (PG) is a modern tool of personalising treatment protocols to improve the efficacy and safety of drug prescriptions. These benefits are offset by a slow uptake in clinical application due to a host of physician factors, patient factors and/or health system factors. Our study, thus, aimed to determine the knowledge, attitude, future expectations and perceived barriers of medical students and physicians in Jordan regarding PG testing. ⋯ Physicians and medical students in Jordan have low overall knowledge, albeit strongly positive attitude and future expectations towards PG, despite the perceived high cost and lack of clinical guidelines. Thus, we strongly recommend adopting a comprehensive educational strategy that aims to integrate PG concepts into medical curricula, and promote the culture of continuous medical education about PG among practitioners.
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Int. J. Clin. Pract. · Jan 2021
Dyskalemias in patients with acute kidney injury presenting to the emergency department are common and independent predictors of adverse outcome.
No data concerning the prevalence and risk factors of dyskalemia in acute kidney injury (AKI) exist. We investigated (a) prevalence rates, (b) risk factors and (c) outcome of hypo- and hyperkalemia in emergency patients. ⋯ Dyskalemias are common in emergency patients with AKI and are independent risk factors for adverse outcomes. Potassium-sparing diuretics, ACE-inhibitors, AKIN stage and CKD are predictors of hyperkalemia in AKI.
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Int. J. Clin. Pract. · Jan 2021
Evaluation of the relationship between androgenetic alopecia and blood groups and Rhesus factor.
Androgenetic alopecia (AGA) is the most common type of hair loss. Androgens and genetic factors are responsible for pathogenesis. Blood groups are genetic markers that are used to identify human gene variation. The aim of this study was to evaluate the blood group distribution in patients with AGA and to compare it with healthy population. ⋯ We could not find any relationship between AGA and blood groups. However, in order to determine this relationship more clearly, further multicentre studies including more cases and investigating subgroups of the cases are needed.
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Int. J. Clin. Pract. · Jan 2021
Epidemiology, risk factors, treatment and outcome of Candida bloodstream infections because of Candida albicans and Candida non-albicans in two district general hospitals in the United Kingdom.
Bloodstream infections caused by Candida species, known as candidemia are on the rise because of increasing complexity of surgical procedures, patient's underlying co-morbidities and shift in patient's demographics. This study was conducted to evaluate the epidemiology, risk factors, co-morbidities, antifungal treatment and outcomes of candidemia in Candida albicans (C. albicans) and Candida non-albicans (C. non-albicans) in East Sussex Healthcare Trust (ESHT), England. ⋯ C. albicans candidemia, >65 years of age and surgical procedure is associated with significant mortality, however, the use of fluconazole has shown the increased survival rate. This study suggests the surveillance of candidemia, and antifungal susceptibility pattern in current practice and the treatment.