International journal of clinical practice
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Adult-onset Still's disease (AOSD) is a rare and non-familial auto-inflammatory disorder. Increased levels of IL-6 and other pro-inflammatory cytokines have been shown in AOSD. To evaluate the efficacy and safety profile of tocilizumab (TCZ), an IL-6 receptor antagonist monoclonal antibody, in AOSD. ⋯ TCZ is an effective and well-tolerated treatment option for treatment resistant AOSD and contributes to the glucocorticoid-sparing. Since TCZ is a new drug in the treatment of AOSD, further studies are needed to assess whether the complications reported during the treatment are because of TCZ or natural course of the disease or coincidental findings.
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Int. J. Clin. Pract. · Mar 2021
Effects of hookah and cigarette smoking on the recovery after septoplasty.
Hookah is a tobacco product of Middle Eastern origin; however, its popularity increases in Europe and the US. Despite its frequent use, hookah's potentially detrimental effects are underestimated as a result of the scarcity of the relevant research. Since septoplasty is one of the most commonly performed procedures of otolaryngology practice, we aimed to investigate the impact of hookah consumption on recovery after septoplasty. ⋯ Patients should be questioned about hookah smoking in addition to cigarette smoking before the septoplasty procedure. Patients with a positive history of hookah smoking should be followed closely in terms of delayed healing and increased septal perforation rates.
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Extraordinary steps have been taken to alleviate the current quick transmission of the Jordanian COVID-19 pandemic. The obligatory lock-down affects their obedience to measures to fight COVID-19. ⋯ Violence continues to be a significant social problem in our society today, yet, continues to be poorly understood. The underlying causes and theories of violence are often not agreed upon by experts in the field. Providing education programmes and essential resources for women that aim to promote the prevention of COVID-19 violence and help Jordanian people to be confident and observe the right behaviour.
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Int. J. Clin. Pract. · Mar 2021
Multicenter Study Observational StudyGender-related clinical and management differences in patients with chronic heart failure with reduced ejection fraction.
Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard. ⋯ In summary, although management seemed to be equivalent between genders, women tended to present with more symptoms, require hospitalisation more frequently and have different comorbidities than men. These results highlight the importance of gender-related differences in HFrEF and call for further research to clarify the causes of these disparities. Gender-specific recommendations should be included in future guidelines in HFrEF.