International journal of clinical practice
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Int. J. Clin. Pract. · Mar 2021
Treatment Intensification in Type 2 Diabetes Management after the Failure of Two Oral Hypoglycemic Agents: A Non- Interventional Comparative Study.
The safety and efficacy of treatment approaches in patients with type 2 diabetes mellitus (T2DM) after the failure of two oral hypoglycemic agents (OHAs) was studied. ⋯ Insulin as add-on therapy with OHAs is an option for the management of T2DM where glycemic control is insufficient with two OHAs.
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Int. J. Clin. Pract. · Mar 2021
Independent association of serum uric acid levels with arterial stiffness in the absence of established cardiovascular disorders.
The impact of serum uric acid (SUA) on atherosclerosis has been suspected to be epiphenomenal owing to its close relationship with metabolic abnormalities. The aim of the present study was to evaluate the association between SUA levels and arterial stiffness in the absence of established cardiovascular (CV) disorders. ⋯ High SUA levels have an independent association with increased arterial stiffness even in subjects without established CV disorders.
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Int. J. Clin. Pract. · Mar 2021
Physical Therapist Attitude and Opinion about cervical spine examination: A national Spanish Survey.
A correct examination is essential during a differential diagnosis of neck pain patients. Therefore, the objective of this study was to provide an update on the properties considered most important by physical therapists (PTs) when conducting accessory and physiological movement tests during the cervical spine physical examination. ⋯ Physical therapists face validity in relation to passive accessory intervertebral movement test for assessing spinal segmental motion aspects has been decreasing with more attention devoted to pain responses. The current scepticism regarding the motion properties assessed with these tests is associated with utility aspects such as validity, sensitivity, accuracy and specificity.
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Int. J. Clin. Pract. · Mar 2021
The prospective relationship between low muscle mass and thyroid hormones among 198,069 euthyroid men and women; comparing different definitions of low muscle mass.
The impact of thyroid hormones within normal range on muscle mass remains unknown. We examined the association between new onset of low muscle mass (LMM) and thyroid hormones among euthyroid men and women with three different definitions of LMM in prospective cohort study. ⋯ Among euthyroid men, FT4 had inverse dose-response association with new onset of LMM defined with weight (LMM-W) and BMI (LMM-B). Height squared LMM (LMM-H) had no apparent relationship with any thyroid hormones. Euthyroid women had no dose-responsive association between thyroid hormones and incident LMM.
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Int. J. Clin. Pract. · Mar 2021
Clinical features and outcomes of adults with COVID-19: A systematic review and pooled analysis of the literature.
The 2019 coronavirus disease (COVID-19) has become a global pandemic and the published literature describing the virus has grown exponentially. ⋯ COVID-19 most commonly presents with fever, cough, fatigue and anorexia and among patients with existing hypertension and cardiovascular disease. It is important as serious adverse outcomes can develop such as acute respiratory distress syndrome, acute cardiac injury, acute kidney injury and death.